The most difficult and unpleasant tiles to cut are mosaics, so take all the suite out and give yourself as much of a run as possible.
Mosaics are not rigid tiles, they can stretch when being fitted so can't really be set out millimeter perfect.
The best bet is to lay the sheets out dry and see what works best.
You are making every possible effort to avoid cuts anywhere.
The sheets should be fitted in brickwork fashion, this way it disguises the sheet outlines and makes a continuous effect.
The most important things to consider when fitting mosaics are as follows:-
1/ Preperation, take your time and get everything straight, any time spent preparing will be saved fitting.
2/ Use the correct materials, there are specialist mosaic materials available, specifically Mosaic adhesive and grout by Nicobond, which is a professional spec, don't confuse this with the nasty fix'n'grout available form the DIY sheds.
3/ see number 1.
4/ no really, number 1 will make or break the whole fit.