I realise the tank and boiler are close but...I need one switched live from the programmer in the cellar to the cylinder stat in the attic;
How will the valve know when the thermostat is calling for heat.and another from the prog to the room stat in the hall. Is it okay to use twin & earth leaving the neutral unconnected?
You're not doing it correctly - talking about single wires - running here to there.
As has been said in various posts -
You need to plan it properly and run cables with the necessary number of cores from each appliance and accessory to, normally, one central point.
As your system is so spread out you may need two, I suppose.
You do not use single wires from programmer to thermostat to valve to boiler.