Beta Variant is "interesting". Not much in the way of trials, but AstraZeneca didn't do well against it in South Africa.
(It's another one which is clever at infecting/transmitting more than Wuhan version.)
"10.4% effective". The SA trial was very poor quallity - they didn't check the variant for all the cases, though Beta was prevalent.
It does seem to have variations (in the RBD part of the Spike) which make it a vaccine-escaper. Be wary if you google for it, there's one reference which goes on to mention a test in Qatar which found AZ
was effective, but finding the test they meant elsewhere revealed that was with the pfizer Vaccine
.
Lab tests suggest quite strongly that AZ and the others should be equally (reasonably) effective against Beta, but so far there's no field proof. Suggestion is that exsting vaccines would again, allow a lot of low-level virus but still be effective against more serious cases.
There's another possible catch with AZ - it uses a crippled chimp virus to carry the DNA into the cell. They use strange viruses like that because humans don't have any antibodies to them. But if you keep giving the same virus, antibodies DO accumulate. So a booster vaccine could get clobbered in some people. I don't know what test they have which would detect that happening. Everybody would have
some antibodies tot he chimp virus.
Anyone read further on this?