There are so many ways to wire up these systems. Much will depend upon the positioning of the components of the heating system in relation to each other in your home, the physical layout and construction of your home, the personal preferences of the original installer, and if the system has been modified or altered at some point. So, it's difficult to advise without being physically present. To trace the cable, there ares some clues that can help:
The room thermostat will open and close a motorised valve, (I'm assuming here, as indicated by the wiring, that your system is fitted with a 3-port motorised valve) so the room thermostat won't be connected directly to the boiler.
You know that it's a 3 core and earth cable, so that will narrow it down a bit.
The blue wire (if it is connected) will go to a neutral at its origin. (So, it won't for example be the blue wire in terminal 4 of the the Heat link)
Of the two live wires (Red and Yellow) one will be connected to terminal 3 of the Heat link (usually the red one) and the other, will go to the motorised valve. (white wire if it's a 3-port valve) They probably won't go directly, but may pass through a junction box and may even change colour when doing so.
Once you have identified the cable it should be tested with a multimeter to make sure you have located the correct one.