I looked at my brother-in-laws system, hot water solar panels, electric solar panels and immersion heat to use excess power, wood burner, and an oil central heating boiler all fed two megaflow units which were very large, the central heating was heated from the megaflow and using the heating only when home he never used the oil central heating boiler, it was fitted when the house was built, however looking at over £16,000 worth of kit, and you get a lot of oil for £16,000.
He told me is was a nightmare to set up, because of using the megaflow as a heat store for the central heating, the normal way to use a condensation boiler is for flame hight to vary to maintain the return water at the correct temperature, however with the megaflow it was a case of flat out until the tank had a set amount of heat, leaving room for the solar and wood burner to add more, then switch off. The boiler heat exchanger was at the bottom of the megaflow so the return water was cold and the sensors were near top of megaflow to switch boiler off.
It seems the Wilis system is far better, where the heat exchangers are not in the main tank, but only the Irish seem to be able to work it out!
Anyway with his system the room thermostat connected to the motorised valve and circulation pump, not the boiler.
Nest or Hive would have worked well for him, except there is intermittent internet and no mobile phone coverage. Which it seemed stopped the Nest or Hive working. Plus it had an over ride to switch on the central heating if the Megaflow got too hot, which could happen if you had a roaring wood fire going. The insurance required the system to be inspected once a year, which was not cheap, and he also had UPS to ensure pumps did not fail. I would not want to play around with a system like that.
It was one of those systems where the rich could boost on how environmental friendly they we are. But it could not have saved him any money.
Personally I did not want Nest, I know when I want heat weeks in advance, no earthly need to alter heating with the phone, however the programmable wireless thermostat simply did not work, it did not do what it said on the box, only way to be sure a wireless device does as it should is two way coms. So sending a signal switch off boiler without getting a signal back to say OK got that is useless, well OK it could simply be if no signal received in an hour turn off boiler, but there is nothing in the thermostat details which tell you what it does, but if you can read the room temperature and it says "Last seen less than 1 minute ago" you know coms have not been lost. With my hard wired programmable thermostat OK, however even with that it has failed due to batteries too low even when the low battery light is off, but my eTRV reports "Battery Voltage: 2.94141V (Reported 28 minutes ago)" it actually tells you the battery voltage.
So it's nothing to do with being able to program with phone, it's all down to actually working. And I have every intention of fitting NEST because it works, not because I can alter it from phone, just because it works. However until we know how the Megaflow is plumbed and wired into the system, advising on how to wire is really not possible. And if the poster knows how it is wired then he would not be asking the question.