Can't think why you'd 'double up' trimmers.
Why not start tiling the first few rows, then you can see where the edges are going to land. Then line up the windows accordingly.
That's what I do.
You can obviously have an equal number of tiles between the the frames.
I wouldn't take too much notice of the instructions showing them being fixed to the main timbers. You can always add some additional timber alongside the spars and noggins if necessary.
Why not start tiling the first few rows, then you can see where the edges are going to land. Then line up the windows accordingly.
That's what I do.
You can obviously have an equal number of tiles between the the frames.
I wouldn't take too much notice of the instructions showing them being fixed to the main timbers. You can always add some additional timber alongside the spars and noggins if necessary.