If you are prepared to plan and are handy, then a it is possible to achieve good results without being a professional builder. These are my two latest projects - garage is single skin block with piers, trusses, and cement board cladding on a raft and the garden room is SIPs on a wood sub frame and easypad foundation, again clad in cement board. Both with slate roofs. The garden room is fully finished with plasterboard, plaster, joinery etc. Garage cost £10K in materials during lockdown, the garden room £15K in materials recently finished. Plus a bit for electrics. Both projects 100% my and wife's work - apart from electrics, we planned and did the lot.
The challenge is going to be building control - both these projects didn't need it, but this is where you are going to need to be very careful with self-build. As
@kingandy2nd has shown in his thread with a much bigger project than mine, it IS possible to DIY a build.