Yes, if the said "thing" is covered by one or more Directives. (Or, more precisely, the national regulations derived from those Directives)I truly don't fully understand. I think what is probably being said is that it does, indeed, apply to "anything 'home-made' " if that anything (even if only a unique one-off) is used in any sort of commercial premises within the EU, the only exception being if the item is used in non-commercial premises. Is that what is perfectly clear to you?
The language varies a little between different Directives, but they are all stating substantially the same thing about placing on the market and putting (or sometimes taking) into service.