I wouldn't have thought it will get in the way of the ladder and it doesn't matter if its hanging in the middle of the room when the ladder's down.
Is there a loft ladder? I can't see one on the visible short side and there can't be one on the other short side as it would extend into the bath. I presumed a normal ladder would be used.
How much the open hatch is in the way will depend on how much space there is and where it is, we can only see a small bit of the room. But in any case I would have thought it better to have the hatch as out of the way as possible, not just for climbing up and down but for handing things in and out.