Are you talking about a screw on the enclosure (which, incidentally, WagoBoxes don't have)? If so,then what about all the 'accessible' electric accessories in your house - whose faceplates are 'only' secured by screws (which "can mechanically loosen"?). ... or are you perhaps talking about screws in the floorboards?
This is all so incredibly hypothetical. If a JB is in an 'inaccessible' location, how on earth would any screws securing it "mechanically loosen" to the extent of presenting any risk to someone was managed to 'access' it? Are you thinking about 'rodents with screwdrivers', oee what?
Kind Regards, John