I friend had this problem with a combi when the system was extended with rads in the attic extension. Replacing existing pipes under floors was not an option because of new flooring. The loop for the attic rads was a spur off the existing rad loop. The new rads had thermostatic valves on them. The engineer said there is two choices of pump location. One on the flow of the new spur to the attic or on the return to the boiler at the boiler. The pump was to be a Grundfos Alpha that turns off when all rads are throttled down. The engineer preferred having the pump on the spur loop as this is where it needed boosting and there was space for it. It was put there and switched from the programmer clock. It worked well and would wind itself off when the attic rad's thermostatic valves shut down. When the combi was on DHW the pump would stop if there was no water flow. The attic rads needed their lockshield valves screwing down to prevent robbing too much flow from the rest of the system.
The engineer said there may be some reverse circulation when drawing off DHW when the 3-way valve in the combi moved over, but none when in normal CH mode, so only a very minor problem.
It worked and gave no problems at all. He did offer a cheaper Wilo Smart pump, but the Grundfos was used because of reputation.