Be careful, you can't just keep lowering the boiler rating and pump settings etc chasing a nirvana differential. The system needs balanced alongside range rating and close control of space temps so the stat stops calling. Target return temps is reached by balancing the system so the radiators release the required heat into the space to maximise room warm up at the same time reaching 50Deg or lower at the boiler return to maximise condensing, thereby maximising efficiency.
Do note though, it is not a perfect science as there are a whole host of variables that are constantly changing, so there has to be a happy medium being as close to the ideal as possible.