bottom gatevalve might need opening further.
Can I have a go too Chris, with all that ptfe on the gatevalve threads, are you sure that you haven't partially closed off one of the pipe ends.
Later.. the outlet connection from the cylinder coil is only 15mm. This will restrict the flow and the size reduction might be a point where a blockage could arise. You also have a by-pass pipe with a valve, the one that joins the return from the coil just after the gate valve. The gate valve on the by-pass should be almost shut since it is only likely to be required when all the heating circuit TRVs are shutting down.
And no TRVs (no apostrophe!) on the rads? I think it's 1970s or thereabouts. That means the cylinder could have a minimally sized coil in it. But you need to check that coil return connection for a blockage.The house is fairly new
except the by-pass gate that forces water though the cylinder coil.
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