Hi Masona!,
I've considered applying the mains pressure to a radiator valve or even a drain plug and came to the conclusion it would not work.
The way I see it is that the 'flow' pipe leaving the boiler becomes the 'return' pipe going back to the boiler with the pump pushing the water in one direction only, making a complete circuit
Now the two vertical pipes ( water pipe from tank & expansion/overflow pipe) both connect to the above mentioned circuit. Where they connect may only be inches apart or it could be a few feet.
Now if there was a blockage say in the water pipe from the tank and the mains supply was applied to the drain or radiator valve it would take the path of least resistance and water would exit from the expansion/overflow pipe.
If the blockage was in the 'flow' or 'return' pipe it would still by-pass the blockage by going in the opposite direction and exit through one the vertical pipes.
Even if the expansion/overflow pipe was temporarily capped and water came up through the pipe from the water tank there is no guarantee the blockage has been moved.
If the mains was applied to the overflow pipe it could still by-pass the blockage.
The secret to this problem I believe is to alternate the direction of the water being pumped to loosen and flush any sediment away.
Some years ago I purchased small black & decker plastic pump (£10) that will take clear plastiic tubing on inlet and outlet and is for use with an electric drill and I often wonder how effective it would be in curing the blockage problem.