I have a large dog, she is 5% Akita, 25% German Shepherd and 25% Husky, also 100% Diva, 200% lovable.
While she wouldn't hurt any of us she would I think defend the house against intruders, certainly if they were to attack me or the wife.
Other than that i'm pretty sure that she will not hurt anyone unless they were aggressive towards her or us and then she'd only be protecting her family.
Best thing I could have done in the past 20 years was to get her, 2nd biggest and the fastest dog in the local park - regurarily plays with jack russels, cockapoos, chiawowas. (spellcheckers not picking that up?).