Ok having just given a recent brief to fellow engineers on this matter, I might be able to help explain not only what an interlock is, but how to answer your question (I said might)
An interlock is by definition either, 'safety' or 'efficiency'
A safety interlock can be an air pressure switch, an over heat thermostat or anything that prevents an appliance from firing up if it would result in the appliance nor being safe. A flow switch within the boiler on the primary circuit would be a safety interlock as would a low water pressure cut off device, both of which would prevent the appliance from firing if no water is present, or pump failure/blockage.
There are of course several other types of safety interlock.
An efficiency interlock is a device that prevents the appliance from firing up for reasons of efficiency. This can be a time clock, or devices such as a room thermostat.
A zone valve could be described as both, it shuts off the boiler in conjunction with the room/cylinder thermostat, or if fitted on an unvented cylinder with a mid position valve the E.C.O. valve acts as a secondary safety device preventing flow to the cylinder if the overheat stat goes closed circuit, but we digress.
So now lets get back to the original question.
Option 1:
yes, this is quite possible and is how I run the heating in my house. I have my room stat set to 24*c in the evening but the only rads that will ever get this high are the front room rads on maximum (about 30*c I believe) and my hall rad which is my control/bypass rad. More on this rad later. The other radiators throughout the house are set from any where between 10* - 20*c so that each room reaches temperature they shut down rather than heating rooms that I don't require heating to full capacity.
Option 2:
Yes, this too is possible. I could set my TRVS to 25*c and leave my room thermostat at 18*c. However as a heating engineer, why ?
It demonstrates a lack of understanding of the system and the majority of my late night call outs relate to this question.
Option 3:
Now we are getting somewhere. This is how a heating system should be installed. Where ever the room thermostat is located the radiator in that location should not have a TRV on it, this is to allow it to act as a control radiator for the room thermostat, else wise if you turn that TRV too low the room stat will never achieve temperature and the boiler will never turn off until the end of its timed demand.
The radiator in this location should be sized accordingly (never is though is it, let's be honest neither is mine) if it is too small it will never achieve set point temperature if it is too large it will achieve it too soon.
The point you make at the end of option 3 is extremely valid and basically true, but here's the ring dinger. Central heating is an art, not rocket science. I could almost achieve what you are asking, the cost of setting it all up correctly and the time involved far out ways the benefit.
Just like I could achieve the stated miles per galleon car manufactures claim, but to do so would mean lowering car tyre pressure, never travelling up a hill and many other factors that I can't be bothered with when taxiing the kids around.
Like far greater minds than mine have said, it's a bit of a compromise.
Does this explain it any better? Or am I just rambling after a 70hr week.