Maybe, but it wouldn't really be necessary. No-one (and no regulation) is saying that the 'single point of isolation ' for the installation cannot be duplicated - so the main switch could remain, with the separate external upstream isolator wired to it, just as is the case with millions of domestic installations which have had an 'isolator' installed upstream of the CU (to facilitate work on the CU, or whatever).Now, if someone were to produce a 100a DP din rail mounting connector block designed to replace the isolator in the CU and link the tails to the busbar and neutral block, that might be a nice solution. I guess each manufacturer would have to do their own and type test it in their own CU - demand would probably not be great enough for them to do that.
... and I don't see any safety downside to that. In an emergency/panic, it wouldn't matter which of the two 'isolators' the householder chose to operate ... or am I missing something?
However, as I've said, I don't think that a 'horizontal' Main Switch is really a problem/issue, anyway.
Kind Regards, John